High riskAfrica · Eastern AfricaDjibouti Travel Health Guide
High risk
Djibouti carries a CDC Level 2 travel health notice. Malaria risk exists throughout Djibouti. Key travel vaccines: COVID-19, Hepatitis A, Hepatitis B. Yellow fever vaccination not needed for disease protection but required for entry if traveling from countries with yellow fever risk, including airport layovers over 12 hours.
Overall risk
High risk
Malaria
Present
Best time to visit
Year-round
Recommended vaccines
Routine Vaccines
Make sure all routine vaccinations are current before travel, including chickenpox, tetanus, flu, MMR, polio, and shingles vaccines.
COVID-19
Stay up to date with COVID-19 vaccinations before traveling.
Hepatitis A
Hepatitis A vaccination recommended for all unvaccinated travelers over 1 year old. Special dosing for infants and high-risk travelers.
Hepatitis B
Hepatitis B vaccination recommended for all unvaccinated travelers regardless of age.
Measles
MMR vaccination required for all travelers due to rising measles cases worldwide. Infants 6-11 months need early vaccination.
Polio
Polio vaccination essential due to poliovirus presence in Djibouti. Adults may need booster shot, unvaccinated travelers need complete series.
Typhoid
Typhoid vaccination recommended, especially if visiting rural areas or staying with local families.
Chikungunya
Vaccination not generally recommended - focus on preventing mosquito bites instead.
Rabies
Consider rabies vaccination if you'll be around animals or in rural areas where treatment may not be readily available.
Yellow Fever
Yellow fever vaccination not needed for disease protection but required for entry if traveling from countries with yellow fever risk, including airport layovers over 12 hours.
Disease risks
Malaria risk
Malaria is present in this destination. Prophylaxis medication is recommended.
Malaria risk exists throughout Djibouti. Prescription antimalarial medication is recommended for all travelers. Chloroquine-resistant malaria is present.
Emergency numbers
Police
17
Medical / Ambulance
18
Fire
18
U.S. Embassy
+253-21-453-000
Djibouti travel health FAQ
Do I need vaccines to travel to Djibouti?▼
For travel to Djibouti, Routine Vaccines, COVID-19, Hepatitis A, Hepatitis B, Measles, Polio and Typhoid are recommended; Chikungunya, Rabies and Yellow Fever may be advised depending on your itinerary. Make sure your routine vaccinations (such as MMR, Tdap, polio and seasonal flu) are up to date, and see a travel-health provider about 4–6 weeks before you leave.
Is there malaria in Djibouti?▼
Yes — malaria is present in Djibouti. Antimalarial prophylaxis is recommended for most travelers, alongside insect-bite precautions such as repellent and treated bed nets.
Is it safe to travel to Djibouti?▼
From a travel-health standpoint, Djibouti is currently rated high risk. Djibouti carries a CDC Level 2 travel health notice. Malaria risk exists throughout Djibouti. Key travel vaccines: COVID-19, Hepatitis A, Hepatitis B. Yellow fever vaccination not needed for disease protection but required for entry if traveling from countries with yellow fever risk, including airport layovers over 12 hours.
What are the emergency phone numbers in Djibouti?▼
Key emergency numbers in Djibouti are Police 17, Medical / Ambulance 18, Fire 18 and U.S. Embassy +253-21-453-000. Save them before you travel and confirm the current numbers with your accommodation on arrival.
More country guides
British Indian Ocean TerritoryLow riskBritish Indian Ocean Territory carries a CDC Level 1 travel health notice. No malaria risk. Key travel vaccines: COVID-19, Hepatitis A, Hepatitis B.
BurundiHigh riskBurundi carries a CDC Level 1 travel health notice. Malaria risk exists throughout Burundi year-round. Key travel vaccines: COVID-19, Hepatitis A, Hepatitis B.
ComorosHigh riskComoros carries a CDC Level 1 travel health notice. Malaria risk exists throughout Comoros. Key travel vaccines: COVID-19, Hepatitis A, Hepatitis B.
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Build my Trip KitSources: CDC Travelers' Health · WHO International Travel and Health. Last updated 2026-07-31. Health conditions and entry rules change — verify with the CDC, WHO and your destination’s authorities before travel. This page is informational and not a substitute for advice from a travel-medicine provider.